Formulation and in Vitro Evaluation of Famotidine Floating Tablets by Lipid Solid Dispersion Spray Drying Technique

The purpose of this investigation was to prepare a gastro retentive drug delivery system of famotidine tablets. Floating tablets of famotidine were prepared employing lipid solid dispersion spray drying technique with gelucire 50/13 and compritol 888 along with HPMC K100M, lactose, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The effect of release enhancer on drug release profile and floating properties were investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. Formulation containing gelucire 50/13 and compritol 888 with HPMC K100M (FT5 & FT8) showed good results in invitro buoyancy, but formulation containing gelucire 50/13 and compritol 888 alone failed to float. Increase in the HPMC K100M level was found to increase the floating time of the tablets. From the results it was concluded that famotidine loaded lipid solid dispersion floating tablets prepared by spray drying method is efficient technique for gastro retentive dosage form.